What MRCP Part 2 asks most often
We counted how often core concepts appear across roughly 9,400 Part 2–style practice question texts from leading revision resources. Below are the concepts that come up most in each specialty, with how many of our own questions test each one (tap the number, or the button under each table, to practise them) and the library topic that teaches it.
✓ Analysis October 2026 · specialties ordered by their share of the examCardiology
About 19 of the 200 exam questions · top 15 concepts
Respiratory medicine
About 19 of the 200 exam questions · top 15 concepts
Gastroenterology & hepatology
About 19 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Coeliac | 5 ▸ | Coeliac disease, malabsorption and nutrition | |
| 2 | Cirrhosis | 16 ▸ | Cirrhosis, portal hypertension and liver failure | |
| 3 | Crohn | 10 ▸ | Inflammatory bowel disease | |
| 4 | Ulcerative colitis | 6 ▸ | Inflammatory bowel disease | |
| 5 | Pancreatitis | 8 ▸ | Pancreatic and biliary disease | |
| 6 | Paracetamol overdose | 8 ▸ | Viral, autoimmune and drug-induced hepatitis including paracetamol | |
| 7 | Ascites/SBP | 12 ▸ | Cirrhosis, portal hypertension and liver failure | |
| 8 | Hepatitis B | 8 ▸ | Viral, autoimmune and drug-induced hepatitis including paracetamol | |
| 9 | Varices | 4 ▸ | Cirrhosis, portal hypertension and liver failure | |
| 10 | Hepatitis C | 4 ▸ | Cirrhosis, portal hypertension and liver failure | |
| 11 | Wilson | 3 ▸ | Abnormal liver tests and inherited liver disease | |
| 12 | Haemochromatosis | 2 ▸ | Abnormal liver tests and inherited liver disease | |
| 13 | IBS | – | – | |
| 14 | PBC | 2 ▸ | Abnormal liver tests and inherited liver disease | |
| 15 | Neuroendocrine/carcinoid | 2 ▸ | Pancreatic and biliary disease |
Endocrinology & diabetes
About 19 of the 200 exam questions · top 15 concepts
Renal medicine
About 19 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Contrast/drug nephrotoxicity | 19 ▸ | Kidney stones, UTI and obstruction | |
| 2 | Transplant | 21 ▸ | Renal transplantation and immunosuppression | |
| 3 | CKD | 21 ▸ | Chronic kidney disease, anaemia and bone disease | |
| 4 | Hypokalaemia | 6 ▸ | Electrolyte and acid–base disorders | |
| 5 | UTI | 6 ▸ | Kidney stones, UTI and obstruction | |
| 6 | ANCA | 11 ▸ | Glomerulonephritis and renal vasculitis | |
| 7 | Hyperkalaemia | 7 ▸ | Renal transplantation and immunosuppression | |
| 8 | Stones | 14 ▸ | Kidney stones, UTI and obstruction | |
| 9 | Anti-GBM | 6 ▸ | Glomerulonephritis and renal vasculitis | |
| 10 | AKI | 19 ▸ | Acute kidney injury including contrast and drug nephrotoxicity | |
| 11 | Dialysis | 29 ▸ | Dialysis and its complications | |
| 12 | Nephrotic | 3 ▸ | Nephrotic syndrome and systemic disease in the kidney | |
| 13 | Metabolic acidosis | 1 ▸ | Electrolyte and acid–base disorders | |
| 14 | ADPKD | 5 ▸ | Inherited and tubular kidney disease | |
| 15 | Membranous | 4 ▸ | Nephrotic syndrome and systemic disease in the kidney |
Infectious diseases
About 19 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | HIV | 43 ▸ | HIV – presentation, opportunistic infection and ART | |
| 2 | Returned traveller | 16 ▸ | The returned traveller and tropical infection | |
| 3 | Sepsis | 7 ▸ | Infection in the immunocompromised host and healthcare-associated infection | |
| 4 | HSV | 9 ▸ | Sexually transmitted infections | |
| 5 | Endocarditis | 5 ▸ | CNS infection | |
| 6 | PEP/PrEP and prophylaxis | 21 ▸ | Immunisation, prophylaxis and infection control | |
| 7 | Gentamicin/vancomycin | 9 ▸ | Sepsis, antimicrobial choice and stewardship | |
| 8 | CMV | 5 ▸ | HIV – presentation, opportunistic infection and ART | |
| 9 | Influenza | 5 ▸ | Immunisation, prophylaxis and infection control | |
| 10 | Syphilis | 6 ▸ | Sexually transmitted infections | |
| 11 | Chlamydia | 4 ▸ | Sexually transmitted infections | |
| 12 | Vaccination | 22 ▸ | Immunisation, prophylaxis and infection control | |
| 13 | VZV | 4 ▸ | Immunisation, prophylaxis and infection control | |
| 14 | Pneumocystis | 2 ▸ | HIV – presentation, opportunistic infection and ART | |
| 15 | Lyme | 3 ▸ | Zoonoses, bites and tick-borne infection |
Clinical pharmacology
About 18 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Warfarin | 9 ▸ | Anticoagulants, antiplatelets and reversal | |
| 2 | Azathioprine/TPMT | 7 ▸ | Drug interactions and therapeutic drug monitoring | |
| 3 | Paracetamol | 3 ▸ | Poisoning and overdose management | |
| 4 | ACE inhibitors | 11 ▸ | Anticoagulants, antiplatelets and reversal | |
| 5 | Drug myopathy | 6 ▸ | Adverse drug reactions and MHRA safety alerts | |
| 6 | Overdose | 8 ▸ | Poisoning and overdose management | |
| 7 | Allopurinol | 4 ▸ | Drug interactions and therapeutic drug monitoring | |
| 8 | CYP450 | 9 ▸ | Drug interactions and therapeutic drug monitoring | |
| 9 | Tricyclics | 2 ▸ | Poisoning and overdose management | |
| 10 | Teratogens | 12 ▸ | Prescribing in pregnancy, breastfeeding and older people | |
| 11 | Lithium | 2 ▸ | Poisoning and overdose management | |
| 12 | Interactions | 6 ▸ | Drug interactions and therapeutic drug monitoring | |
| 13 | Aminoglycosides | 2 ▸ | Drug interactions and therapeutic drug monitoring | |
| 14 | Carbon monoxide | 2 ▸ | Poisoning and overdose management | |
| 15 | Theophylline | – | – |
Neurology
About 17 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Seizures/epilepsy | 27 ▸ | Seizures and epilepsy | |
| 2 | Stroke | 14 ▸ | Stroke, TIA and cerebral venous thrombosis | |
| 3 | Meningitis | 3 ▸ | Spinal cord, cranial nerves and neuro-ophthalmology | |
| 4 | MS | 10 ▸ | Multiple sclerosis, NMOSD and MOG disease | |
| 5 | Parkinson | 7 ▸ | Movement disorders | |
| 6 | Encephalitis | 5 ▸ | Autoimmune encephalitis, dementia and functional neurological disorder | |
| 7 | MND | 5 ▸ | Spinal cord, cranial nerves and neuro-ophthalmology | |
| 8 | Guillain–Barré | 3 ▸ | Neuromuscular disease and peripheral neuropathy | |
| 9 | Myasthenia | 1 ▸ | Neurological emergencies and driving rules | |
| 10 | NMOSD | 4 ▸ | Multiple sclerosis, NMOSD and MOG disease | |
| 11 | Migraine | 3 ▸ | Headache and raised intracranial pressure | |
| 12 | TIA | 3 ▸ | Neurological emergencies and driving rules | |
| 13 | SAH | 2 ▸ | Headache and raised intracranial pressure | |
| 14 | Thrombectomy/thrombolysis | 5 ▸ | Stroke, TIA and cerebral venous thrombosis | |
| 15 | IIH | 2 ▸ | Headache and raised intracranial pressure |
Dermatology
About 9 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Sarcoidosis skin | 1 ▸ | Skin signs of systemic disease | |
| 2 | Psoriasis | 4 ▸ | Inflammatory skin disease and its systemic treatment | |
| 3 | Eczema | 2 ▸ | Blistering disease | |
| 4 | Erythema nodosum | 1 ▸ | Skin signs of systemic disease | |
| 5 | SCC | 2 ▸ | Skin cancer and transplant skin | |
| 6 | Acne | 1 ▸ | Inflammatory skin disease and its systemic treatment | |
| 7 | Dermatitis herpetiformis | 2 ▸ | Blistering disease | |
| 8 | Urticaria | 1 ▸ | Inflammatory skin disease and its systemic treatment | |
| 9 | Melanoma | 5 ▸ | Skin cancer and transplant skin | |
| 10 | Lichen planus | – | – | |
| 11 | Pyoderma gangrenosum | – | – | |
| 12 | Erythema multiforme | 1 ▸ | Severe cutaneous drug reactions | |
| 13 | Tinea | – | – | |
| 14 | Vitiligo | – | – | |
| 15 | BCC | 2 ▸ | Skin cancer and transplant skin |
Geriatric medicine
About 9 of the 200 exam questions · top 7 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Polypharmacy | 10 ▸ | Falls, syncope and postural hypotension | |
| 2 | Dementia | 11 ▸ | Delirium and dementia | |
| 3 | Falls | 13 ▸ | Falls, syncope and postural hypotension | |
| 4 | Syncope | 4 ▸ | Falls, syncope and postural hypotension | |
| 5 | Incontinence | 3 ▸ | Continence, pressure ulcers and immobility | |
| 6 | Postural hypotension | 9 ▸ | Falls, syncope and postural hypotension | |
| 7 | Delirium | 11 ▸ | Delirium and dementia |
Haematology
About 9 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | AML | 3 ▸ | Myeloid and lymphoid malignancy | |
| 2 | Lymphoma | 3 ▸ | Myeloid and lymphoid malignancy | |
| 3 | Haemolysis | 9 ▸ | Anaemia and haemolysis | |
| 4 | Transfusion | 16 ▸ | Haemoglobinopathies and transfusion | |
| 5 | Warfarin | 4 ▸ | Thrombosis and anticoagulation | |
| 6 | HUS/TMA | 3 ▸ | Bleeding disorders and thrombotic microangiopathy | |
| 7 | Myeloma | 4 ▸ | Myeloma, amyloid and plasma cell disorders | |
| 8 | DIC | 5 ▸ | Anaemia and haemolysis | |
| 9 | Iron deficiency | 3 ▸ | Anaemia and haemolysis | |
| 10 | B12 | 4 ▸ | Anaemia and haemolysis | |
| 11 | Hodgkin | 1 ▸ | Myeloid and lymphoid malignancy | |
| 12 | Amyloid | 3 ▸ | Myeloma, amyloid and plasma cell disorders | |
| 13 | VTE | 6 ▸ | Thrombosis and anticoagulation | |
| 14 | CLL | 1 ▸ | Myeloid and lymphoid malignancy | |
| 15 | Polycythaemia | 1 ▸ | Myeloma, amyloid and plasma cell disorders |
Rheumatology
About 9 of the 200 exam questions · top 15 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | SLE | 8 ▸ | SLE, antiphospholipid syndrome and Sjögren syndrome | |
| 2 | Rheumatoid arthritis | 9 ▸ | Inflammatory arthritis and its treatment | |
| 3 | Vasculitis | 7 ▸ | Vasculitis | |
| 4 | Methotrexate | 8 ▸ | Inflammatory arthritis and its treatment | |
| 5 | ANCA | 5 ▸ | Vasculitis | |
| 6 | Gout | 4 ▸ | Crystal and septic arthritis | |
| 7 | Systemic sclerosis | 4 ▸ | Systemic sclerosis and myositis | |
| 8 | Myositis | 3 ▸ | Systemic sclerosis and myositis | |
| 9 | Anti-TNF | 4 ▸ | Inflammatory arthritis and its treatment | |
| 10 | PAN | – | – | |
| 11 | Reactive arthritis | – | – | |
| 12 | Axial SpA | – | – | |
| 13 | Behçet | 1 ▸ | Vasculitis | |
| 14 | Marfan | – | – | |
| 15 | Septic arthritis | 2 ▸ | Crystal and septic arthritis |
Oncology
About 6 of the 200 exam questions · top 14 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Chemotherapy toxicity | 9 ▸ | Cancer of unknown primary and tumour markers | |
| 2 | Lung cancer | 5 ▸ | Cancer genetics, screening and paraneoplastic syndromes | |
| 3 | Radiotherapy | 6 ▸ | Oncological emergencies | |
| 4 | Paraneoplastic | 3 ▸ | Cancer genetics, screening and paraneoplastic syndromes | |
| 5 | Breast cancer | 6 ▸ | Cancer genetics, screening and paraneoplastic syndromes | |
| 6 | Tumour markers | 8 ▸ | Cancer of unknown primary and tumour markers | |
| 7 | Germ cell | 6 ▸ | Cancer of unknown primary and tumour markers | |
| 8 | Prostate cancer | 1 ▸ | Oncological emergencies | |
| 9 | Neutropenic sepsis | 2 ▸ | Oncological emergencies | |
| 10 | MSCC | 2 ▸ | Oncological emergencies | |
| 11 | SVCO | 1 ▸ | Oncological emergencies | |
| 12 | Tumour lysis | 2 ▸ | Cancer of unknown primary and tumour markers | |
| 13 | BRCA | 2 ▸ | Cancer genetics, screening and paraneoplastic syndromes | |
| 14 | Checkpoint inhibitor toxicity | 8 ▸ | Systemic anticancer therapy and immunotherapy toxicity |
Ophthalmology
About 3 of the 200 exam questions · top 14 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Fundus in systemic disease | 7 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 2 | Papilloedema | 1 ▸ | Optic nerve, pupils and visual loss | |
| 3 | Uveitis | 3 ▸ | Red eye, uveitis and scleritis | |
| 4 | Glaucoma | 1 ▸ | Red eye, uveitis and scleritis | |
| 5 | Optic neuritis | – | – | |
| 6 | Diabetic retinopathy | – | – | |
| 7 | RVO | 1 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 8 | Hypertensive retinopathy | 1 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 9 | Cataract | 2 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 10 | RAO | 2 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 11 | Retinitis pigmentosa | – | – | |
| 12 | GCA | 4 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 13 | AMD | 1 ▸ | Retinal vascular disease and the fundus in systemic disease | |
| 14 | CMV retinitis | – | – |
Palliative & end of life care
About 3 of the 200 exam questions · top 6 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Breathlessness | 4 ▸ | Symptom control in palliative care | |
| 2 | Bowel obstruction | 1 ▸ | Symptom control in palliative care | |
| 3 | Opioids | 9 ▸ | Pain and opioid prescribing | |
| 4 | Antiemetics | 4 ▸ | Pain and opioid prescribing | |
| 5 | Breakthrough pain | 1 ▸ | Care in the last days of life and decision-making | |
| 6 | DNACPR | 1 ▸ | Care in the last days of life and decision-making |
Psychiatry
About 3 of the 200 exam questions · top 14 concepts
| # | Concept | How often it comes up | Our questions (tap to practise) | Study it |
|---|---|---|---|---|
| 1 | Depression | 1 ▸ | Mood disorders, psychosis and psychotropic toxicity | |
| 2 | Eating disorders | 3 ▸ | Alcohol, substance misuse and eating disorders | |
| 3 | Functional/somatic | 1 ▸ | Capacity, the Mental Health Act and self-harm | |
| 4 | Capacity | 5 ▸ | Capacity, the Mental Health Act and self-harm | |
| 5 | SSRIs | – | – | |
| 6 | Lithium | 3 ▸ | Mood disorders, psychosis and psychotropic toxicity | |
| 7 | Antipsychotics | 4 ▸ | Mood disorders, psychosis and psychotropic toxicity | |
| 8 | Self-harm | 6 ▸ | Mood disorders, psychosis and psychotropic toxicity | |
| 9 | Schizophrenia | 2 ▸ | Mood disorders, psychosis and psychotropic toxicity | |
| 10 | Bipolar | 3 ▸ | Mood disorders, psychosis and psychotropic toxicity | |
| 11 | Alcohol withdrawal | 3 ▸ | Alcohol, substance misuse and eating disorders | |
| 12 | OCD | – | – | |
| 13 | Personality disorder | 1 ▸ | Capacity, the Mental Health Act and self-harm | |
| 14 | Clozapine | 1 ▸ | Mood disorders, psychosis and psychotropic toxicity |
How often a concept appears in revision banks is a guide to what is high-yield, not a list of real exam questions. MRCP(UK) questions are confidential; every question and note on MedEd World is original. Independent exam prep – not affiliated with MRCP(UK), the Federation or the Royal Colleges of Physicians.